PRP (Platelet-Rich Plasma) and Women's Reproductive Health: Current Status

New Generation Technologies and Sustainability In Health : Current Studies

Editors: Fatma Nur TAKI, Sabri KOÇER, Resul BÜTÜNER


New Generation Technologies and Sustainability In Health : Current Studies

86

PRP (Platelet-Rich Plasma) and Women's Reproductive Health: Current Status

Chapter Authors: Elif GÜLBAHÇE MUTLU, Hatice Nur ŞEFLEK

Pages: 96-118

This section reviews research on the use of Platelet Rich Plasma (PRP) in reproductive medicine, focusing on its potential to improve endometrial thickness, implantation rates and ovarian function in women with infertility. Increasing Endometrial Thickness: PRP shows potential to increase endometrial thickness in women with thin endometrium (<7 mm). PRP treatment stimulates the proliferation and regeneration of endometrial cells through growth factors and cytokines, leading to a thicker and more receptive endometrium. Improvement of Ovarian Function: PRP can rejuvenate and improve ovarian function, especially for women with low ovarian reserve, such as those with primary ovarian insufficiency (POI) or poor ovarian response (POR). Improving Implantation Success: PRP may increase the likelihood of embryo attachment to the uterus by increasing endometrial receptivity. This is particularly advantageous for women who experience recurrent implantation failure (RIF), as improved receptivity can help overcome this significant obstacle. Gene Expression and PRP: PRP may influence endometrial receptivity by regulating the expression of implantation-related genes such as COX-2, TP53, ER-α and ER-β, and progesterone receptors. Conclusion: PRP therapy shows promise in improving key aspects of reproductive health, including endometrial thickness, ovarian function and implantation success. Continued research is needed to optimise treatment protocols and develop personalised approaches, to ensure the effective and safe use of PRP in improving fertility and reproductive outcomes.

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