The section aims to elaborate on the severe side effects of sports supplements and this sport supplement’s details. This systematic review used PRISMA guidelines and PICOS criteria to examine case reports on adverse effects of sports supplements in healthy, drug-free individuals. Following a search of three databases, 25 studies reporting on 39 total cases were included for analysis. The findings reveal that sports supplements cause to organs damage and even death.  The reported cases primarily involved liver and heart damage, with DMAA and caffeine identified as the potential lethal ingredients. Caffeine overdoses averaged 26 times the recommended dose, with specific products like OxyELIT Pro, Caffeine Anhydrous, and Jack 3d linked to organ damage and death. Unapproved sports supplements, often sold online, pose critical risks including organ damage and death due to inappropriate use. This study’s findings aim to raise consumer awareness and guide interventions to reduce these severe side effects.