This chapter introduces a novel approach to reducing the power consumption of battery-constrained sensor applications through the nPZero powersaving chip, manufactured by Nanopower Semiconductor AS. The nPZero is a powersaving chip that acts as an intelligent power management unit (IPMIC) to enable ultralow-power operation in embedded systems at the hardware level without the need for an active host, such as a microcontroller or a wireless system-on-a-chip (SoC) module. Its main purpose is to prevent extra power consumption caused by unnecessary operation of microcontrollers and peripherals (e.g., sensors and communication modules), which are the primary sources of energy required in IoT devices. The nPZero chip provides a significant reduction in current, from the microampere (µA) to the nanoampere (nA) level, thereby extending battery lifetime from weeks to years. As a consequence, battery lifetime extension helps to reduce the volume of annual production and the generation of electronic waste. In the experimental study, NanoPower’s nPZero Evaluation Kit (EVK) was used to verify the validity of an advanced power management in terms of current consumption. The aim is to experimentally evaluate the hardware-based power management approach in terms of current consumption, low-power mode transition performance, and overall power efficiency. The obtained test results show the hardwarebased power management approach not only enhances energy efficiency but also improves thermal stability, system reliability, and long-term circuit robustness.